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One other important result was that patients treated with a single dose of prednisolone were statistically more likely to receive additional doses of the steroid compared to patients treated with 0.1 mg/kg placebo. These findings suggest that the dose of prednisolone should be reconsidered, to better assess the safety of prednisolone therapy in HIV-infected humans.The authors, "Efficacy of a single dose of prednisolone for treatment of HIV/AIDS in a cohort of HIV-infected humans," was published in the Journal of Clinical Endocrinology & Metabolism, online ahead of print, in September.About this HIV Research TopicThe purpose of this HIV Research Topic is to highlight emerging evidence that suggests treatment with prednisolone has efficacy against HIV infection when given as a single oral dose in a cohort of randomized HIV-infected population participants. It contains three primary articles: "Prednisolone for treatment of HIV-infected subjects (Efficacy and safety)," by H. Zang, M. Zang, A. P. Ndidi, C. V. Anwar, G. Chor, A. D. Seng, and C. A. Seneviratne; "FDA preapproval: A review of preapproval studies involving human immunodeficiency virus (HIV) antibody and prophylactic prednisolone regimens in HIV-infected humans," by F. E. Lee, M. J. Chang, M. R. D'Esposito, A. R. Wajsman, and G. J. Bongangarajah; and "HIV-related effects of prednisolone on lymphocyte counts in HIV-infected individuals: A systematic review and meta-analysis," by E. M. F. Seneviratne, H. G. Zang, H. J. Chang, and R. J. Emslie.This research topic will be updated with further published results and findings as new information becomes available. Additional abstracts are available at: https://clinicaltrials.gov/ct2/show/NCT01033985.CITATION: "Efficacy of a single dose of prednisolone for treatment of HIV/AIDS in a cohort of HIV-infected subjects," H. Zang, M. Zang, A. P. Ndidi, C. V. Anwar, G. Chor, A. D. Seng, and C. A. Seneviratne; Journal of ClinicalSimilar articles: